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D-RIBOSE helpful information about this amazing sugar

d-RIBOSE POWDER TO HELP KEEP A HEALTHY HEART

Until 1944, D-ribose was thought to be primarily a structural component of DNA and RNA with little physiological significance. But a series of studies, culminating in 1957, revealed that this sugar molecule played an intermediate role in an important metabolic reaction called the pentose phosphate pathway. This reaction is central to energy synthesis, the production of genetic material, and for providing substances used by certain tissues to make fatty acids and hormones.


The D-ribose connection to cardiac function was made by the physiologist Heinz-Gerd Zimmer at the University of Munich. In 1973, he reported that energy-starved hearts could recover faster if D-ribose was given prior to, or immediately following, ischemia (oxygen deprivation). Five years later, he reported the same effect in skeletal muscle and also showed for the first time that the energy-draining effects of drugs that make the heart beat more strongly (inotropic agents) could be lessened if D-ribose was given along with the drug. Zimmer and his research colleagues later proved that D-ribose was the limiting element in energy recovery in ischemic tissue and that energy synthesis could not occur without it.

Zimmer’s research sparked a flurry of research on humans, rats, rabbits, guinea pigs, dogs, and even turkeys, all with similar results. D-ribose administration significantly improved energy recovery in ischemic, hypoxic, or cardiomyopathic hearts and skeletal muscle, and it improved functional performance of the tissue. In addition, studies with several common heart drugs—those used even today—showed that D-ribose administration did not negatively affect (and in many cases helped) the action of the drug on the heart.


The most significant findings of the studies underscored the dramatic effect that D-ribose administration played in both energy restoration and the return of normal diastolic cardiac function. A clinical study from Zimmer’s group in Munich in 1992 showed that D-ribose administration to patients with severe, stable coronary artery disease increased exercise tolerance and delayed the onset of moderate angina. Since this groundbreaking study in coronary artery disease, the benefits of D-ribose have been reported for cardiac surgery recovery, heart failure and neuromuscular disease treatment, restoration of energy to stressed skeletal muscle, and control of free-radical formation in oxygen-deprived tissue.

 

D-Ribose is a naturally occurring sugar that has shown, with positive results, to generate and recover ATP levels (adenosine triphosphate (ATP) is the body’s primary energy carrying molecule).

ATP levels drop for a number of reasons, high intensity workouts, heart attacks, heart surgery, or other surgeries which can lead to other concerns of fatigue, muscle soreness, or stiffness.

The enhancement of ATP recovery plays a key role in improving overall health, lifestyle, and level of fitness for people with cardiovascular problems as well as in athletes who are exercising extensively and depleting energy reserves.

D-ribose has been under various of studies gaining impressive results:

  • In patients with coronary artery disease and heart failure,  D-ribose improves diastolic functional parameters and enhanced quality of life.
  • D ribose may help some individuals with chronic fatigue syndrome or fibromyalgia.
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  • Oral ribose supplementation (10 grams a day for 5 day) does not affect anaerobic exercise capacity or metabolic markers in trained subjects.
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  • Ribose supplementation does not have a consistent or substantial effect on anaerobic cycle sprinting.
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  • Oral ribose supplementation with 4-g doses four times a day does not help postexercise muscle ATP recovery and maximal intermittent exercise performance.

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